Marion L. Carroll, Ph.D., Assistant Professor

OFFICE:

NCF-305, Laboratory: NCF-304

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Xavier University
Department of Chemistry		
1 Drexel Drive				
New Orleans, LA 70125
Tel	(504) 520-7371
Fax	(504) 520-7942
Email	mlcarrol@xula.edu

EDUCATION:

Ph.D. Biochemistry/Molecular Biology, LSUHS Center, 2001
M.S.  Biochemistry, University of Vermont, 1985
B.S.  Biochemistry, Xavier University, 1983

ABSTRACT:

Dr. Marion Carroll has facilitated the training and successful mentoring of over two dozen undergraduate students in the past five years not only through teaching and mentoring in the biochemistry, proteomics and genomics and organic chemistry courses that he teaches but also by engaging a few of these students in basic scientific research and research presentations locally and nationally. It is his objective to continue providing the tools and projects involving bioinformatics to prepare his students for successful experiences in graduate school. Dr. Carroll’s primary objectives in research have been to characterize the unique subfamily structure of repetitive mobile elements called Alu within non-human primates. Evidence accumulated has suggested a distinct pattern of Alu subfamily structure that has evolved in humans and chimpanzees independently that may contribute to understanding human/great ape divergence. These studies have relied heavily on mining the genome database, sequence alignment, and phylogenetic parsimony, primer design and PCR amplification of genomic DNA. He has identified a new subfamily having unique characteristics in humans and chimpanzees. This search continues in addition to understanding the role that these unique elements may play in human and chimpanzee genetic diversity and phenotypes.

PUBLICATIONS:

1. Cook, J.R., Huang, D.P., Burkhardt, A.L., Goldman, M.E., Carroll, M.L., Bresnick, E. and Chiu, J-F.: Assessment of the antitumor potential of glutathione. Cancer Letters 21: 277, 1984.

2. Wissner, A., Carroll, M.L., Green, K.F., Kerwar, S.S., Pickett, W.C., Schaub, R.E., Torley, L.W., Wrenn, S. and Kohler, C.A.: Analogs of PAF, 6-mono-and Bis-aryl phosphate antagonist of PAF. Journal of Medicinal Chemistry 35: 1650-1662, 1992.

3. Torley, L.W., Pickett, W.C., Carroll, M.L., Kohler, C.A., Schaub, R.E., Wissner, A., Dejoy, S.Q., Oronsky, A.L. and Kerwar, S.S.: Studies of the effect of a PAF antagonist, 184005, in animal models of gram-negative bacterial sepsis. Antimicrobial Agents and Chemotherapy 36: 1971-1977, 1992.

4. Wissner, A., Carroll, M.L., Johnson, B.D., Kerwar, S.S., Pickett, W.C., Schaub, R.F., Torley, L.W., Trova, M.P. and Kohler, C.A.: Analogs of Platelet Activating Factor, 7. Bis-Aryl Amide and Bis-Aryl Urea Receptor Antagonist of PAF. Journal of Medicinal Chemistry 35: 47794789, 1992.

5. Trova, M. P., Wissner, A., Carroll, M.L., Kerwar, S.S., Pickett, W.C., Schaub, R.E., Torley, L.W. and Kohler, C.A.: Analogs of Platelet Activating Factor, 8. Antagonist of PAF Containing an Aromatic Ring Linked to a Pyridinium Ring. Journal of Medicinal Chemistry 36: 580-590, 1993.

6. Kohler, C.A., Carroll, M.L., Tarrant, E., Torley, L.W. and Wissner, A.: Effect of a Series of 1-Alkyl Ether Lipids on Inhibition of Phospholipase A2 Activity and PAF Responses. Inflammation 17: 245-261, 1993.

7. Discafani C.M., Carroll, M.L., Floyd, Jr., M.B., Hollander, I. J., Husain, Z., Johnson, B.D., Kitchen, D., May, M.K., Malo, M.S., Minnick, Jr., A.A., Nilakantan, R., Shen, R., Wang, Y.F., Wissner, A. and Greenberger, L.M.: Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl) amino]-6-quinazolinyl]-2-butynamide (CL-387,785). Biochemical Pharmacology 57: 917-925, 1999.

8. Roy, A.M., Carroll, M.L., Kass, D.H., Nguyen, S.V., Salem, A.-H., Batzer, M.A. and Deininger, P.L. Recently Integrated Human Alu Repeats: Finding Needles in the Haystack. Genetica 107:149-161, 1999.

9. Roy, A.M., Carroll, M.L., Nguyen, S.V., Salem, A-H., Oldridge, M., Wilkie, A.O.M., Batzer, M.A. and Deininger, P.L. Gene Conversion and Retroposition Potential in Recently Integrated Alu Elements. Genome Research 10:1485-1495, 2000.

10. Carroll, M.L., Nguyen, S.V. and Batzer, M.A. Genome Databases. In "Encyclopedia of Life Sciences". Macmillan Reference Limited, Stockton Press, London, U.K., Htttp://www.els.net/elsonline/html/A0003027.html, 2000.

11. Bamshad, M., Kivisild, T., Watkins, S.W., Dixon, M.E., Ricker, C.E., Rao, B.B., Naidu, M.J., Prasad, B.V. R., Reddy, P.G., Rasanayagam, A., Papiha, S. S., Villems, R., Nguyen, S.V., Carroll, M.L., Batzer, M.A. and Jorde, L.B. 2000. Genetics Evidence on the Origins of Indian Caste Populations. Genome Research 11: 450-455, 2001.

12. Watkins, W.S., Ricker, C.E., Bamshad, M.J., Carroll, M.L., Nguyen, S.V., Batzer, M.A. and Jorde, L.B. Patterns of ancestral human diversity: an analysis of Alu insertion and restriction site polymorphisms. American Journal of Human Genetics 68:738-752, 2001.

13. Roy-Engel*, A.M., Carroll*, M.L., Vogel, E., Garber, R. Nguyen, S.V., Salem, A-H, Batzer, M.A. and Deininger, P.L.. Alu Insertion Polymorphisms for the Study of Human Genomic Diversity. Genetics 159:279-290, 2001.

14. Carroll, M.L., Roy, A.M., Nguyen, S.V., Salem, A-H, Vogel, E., Vincent, B., Myers, J., Ahmed, Z., Nguyen, L, Sammarco, M., Watkins, W. S., Jorde, L.B., Deininger, P.L. and Batzer, M.A. Large-scale analysis of Ya5 and Yb8 Alu subfamilies and human genomic diversity. Journal of Molecular Biology 311(1):17-40, 2001.

15. Roy, A.M., Carroll, M.L., El-Sawy, M., Salem, A-H, Garber, R.K., Nguyen, S.V., Deininger, P.L. and Batzer, M.A. Non-traditional Alu Evolution and Primate Genomic Diversity. Journal of Molecular Biology 316:1033-1040, 2002. Cover illustration.

16. Watkins, W.S., Rogers, A.R., Ostler, C.T., Bamshad, M. J., Brassington, A-M. E., Carroll, M.L., Nguyen, S.V., Walker, J.A., Batzer, M.A., and Jorde, L.B. Genetic variation among world populations using 100 Alu insertion polymorphisms. Genome Research 13:1607-1618, 2003.

17. Carroll, M.L. and Ciaffa, J. The Human Genome Project: A Scientific and Ethical Overview., An actionbioscience.org original article. August, 2003.

created by Marion L. Carroll, August 27, 2003